Degenerative Disorders

  • Xiao J, Jin K, Wang J, Ma J, Zhang J, Jiang N, Wang H, Luo X, Fei J, Wang Z, Yang X, Ma D. Conditional knockout of TFPI-1 in VSMCs of mice accelerates atherosclerosis by enhancing AMOT/YAP pathway. Int J Cardiol. 2017 Feb 1;228:605-614. doi: 10.1016/j.ijcard.2016.11.195. Epub, 2016 Nov 12. PubMed 27875740 DOI http://dx.doi.org/10.1016/j.ijcard.2016.11.195
  • Zeng S, Wang K, Huang M, Qiu Q, Xiao Y, Shi M, Zou Y, Yang X, Xu H, Liang L. Halofuginone inhibits TNF-alpha-induced the migration and proliferation of fibroblast-like synoviocytes from rheumatoid arthritis patients. Int Immunopharmacol. 2017 Feb;43:187-194. doi: 10.1016/j.intimp.2016.12.016. Epub, 2016 Dec 23. PubMed 28013187 DOI http://dx.doi.org/10.1016/j.intimp.2016.12.016
  • Lee HK, Kim HS, Kim JS, Kim YG, Park KH, Lee JH, Kim KH, Chang IY, Bae SC, Kim Y, Hong JT, Kehrl JH, Han SB. CCL2 deficient mesenchymal stem cells fail to establish long-lasting contact with T cells and no longer ameliorate lupus symptoms. Sci Rep. 2017 Jan 24;7:41258. doi: 10.1038/srep41258. PubMed 28117437 DOI http://dx.doi.org/10.1038/srep41258
  • Shan K, Li CP, Liu C, Liu X, Yan B. RNCR3: A regulator of diabetes mellitus-related retinal microvascular dysfunction. Biochem Biophys Res Commun. 2017 Jan 22;482(4):777-783. doi:, 10.1016/j.bbrc.2016.11.110. Epub 2016 Nov 19. PubMed 27876564 DOI http://dx.doi.org/10.1016/j.bbrc.2016.11.110
  • Liu Y, Pan YF, Xue YQ, Fang LK, Guo XH, Guo X, Liu M, Mo BY, Yang MR, Liu F, Wu YT, Olsen N, Zheng SG. uPAR promotes tumor-like biologic behaviors of fibroblast-like synoviocytes through PI3K/Akt signaling pathway in patients with rheumatoid arthritis. Cell Mol Immunol. 2017 Jan 16. doi: 10.1038/cmi.2016.60. PubMed 28090093 DOI http://dx.doi.org/10.1038/cmi.2016.60
  • Luo Y, Duan H, Qian Y, Feng L, Wu Z, Wang F, Feng J, Yang D, Qin Z, Yan X. Macrophagic CD146 promotes foam cell formation and retention during atherosclerosis. Cell Res. 2017 Jan 13. doi: 10.1038/cr.2017.8. PubMed 28084332 DOI http://dx.doi.org/10.1038/cr.2017.8
  • Lu Y, Yu SS, Zong M, Fan SS, Lu TB, Gong RH, Sun LS, Fan LY. Glucose-6-Phosphate Isomerase (G6PI) Mediates Hypoxia-Induced Angiogenesis in Rheumatoid Arthritis. Sci Rep. 2017 Jan 9;7:40274. doi: 10.1038/srep40274. PubMed 28067317 DOI http://dx.doi.org/10.1038/srep40274
  • Zhang QS, Heng Y, Yuan YH, Chen NH. Pathological alpha-synuclein exacerbates the progression of Parkinson's disease through microglial activation. Toxicol Lett. 2017 Jan 4;265:30-37. doi: 10.1016/j.toxlet.2016.11.002. Epub 2016 , Nov 16. PubMed 27865851 DOI http://dx.doi.org/10.1016/j.toxlet.2016.11.002
  • Barnat M, Le Friec J, Benstaali C, Humbert S. Huntingtin-Mediated Multipolar-Bipolar Transition of Newborn Cortical Neurons Is Critical for Their Postnatal Neuronal Morphology. Neuron. 2017 Jan 4;93(1):99-114. doi: 10.1016/j.neuron.2016.11.035. Epub 2016 Dec, 22. PubMed 28017473 DOI http://dx.doi.org/10.1016/j.neuron.2016.11.035
  • Shams K, Wilson GJ, Singh M, van den Bogaard EH, Le Brocq ML, Holmes S, Schalkwijk J, Burden AD, McKimmie CS, Graham GJ. Spread of Psoriasiform Inflammation to Remote Tissues Is Restricted by the Atypical Chemokine Receptor ACKR2. J Invest Dermatol. 2017 Jan;137(1):85-94. doi: 10.1016/j.jid.2016.07.039. Epub, 2016 Aug 26. PubMed 27568525 DOI http://dx.doi.org/10.1016/j.jid.2016.07.039
  • Fujisawa T, Wang K, Niu XL, Egginton S, Ahmad S, Hewett P, Kontos CD, Ahmed A. Angiopoietin-1 promotes atherosclerosis by increasing the proportion of circulating Gr1+ monocytes. Cardiovasc Res. 2017 Jan;113(1):81-89. doi: 10.1093/cvr/cvw223. PubMed 28069704 DOI http://dx.doi.org/10.1093/cvr/cvw223
  • Chen Y, Brooks MJ, Gieser L, Swaroop A, Palczewski K. Transcriptome profiling of NIH3T3 cell lines expressing opsin and the P23H opsin mutant identifies candidate drugs for the treatment of retinitis pigmentosa. Pharmacol Res. 2017 Jan;115:1-13. doi: 10.1016/j.phrs.2016.10.031. Epub 2016 Nov , 9. PubMed 27838510 DOI http://dx.doi.org/10.1016/j.phrs.2016.10.031
  • Wang Y, Ma J, Chen L, Xie XL, Jiang H. Inhibition of Focal Adhesion Kinase on Hepatic Stellate-cell Adhesion and Migration. Am J Med Sci. 2017 Jan;353(1):41-48. doi: 10.1016/j.amjms.2016.11.020. Epub 2016 , Nov 17. PubMed 28104102 DOI http://dx.doi.org/10.1016/j.amjms.2016.11.020
  • Kim R, Park SI, Lee CY, Lee J, Kim P, Oh S, Lee H, Lee MY, Kim J, Chung YA, Hwang KC, Maeng LS, Chang W. Alternative new mesenchymal stem cell source exerts tumor tropism through ALCAM and N-cadherin via regulation of microRNA-192 and -218. Mol Cell Biochem. 2016 Dec 30. doi: 10.1007/s11010-016-2909-5. PubMed 28039611 DOI http://dx.doi.org/10.1007/s11010-016-2909-5
  • Ghousifam N, Mortazavian H, Bhowmick R, Vasquez Y, Blum FD, Gappa-Fahlenkamp H. A three-dimensional in vitro model to demonstrate the haptotactic effect of monocyte chemoattractant protein-1 on atherosclerosis-associated monocyte migration. Int J Biol Macromol. 2016 Dec 29;97:141-147. doi: 10.1016/j.ijbiomac.2016.12.072. PubMed 28041913 DOI http://dx.doi.org/10.1016/j.ijbiomac.2016.12.072
  • Ferrer DG, Actis Dato V, Jaldin Fincati JR, Lorenc VE, Sanchez MC, Chiabrando GA. Activated alpha2 -Macroglobulin Induces Mesenchymal Cellular Migration of Raw264.7 Cells through Low-Density Lipoprotein Receptor-Related Protein 1. J Cell Biochem. 2016 Dec 24. doi: 10.1002/jcb.25857. PubMed 28012205 DOI http://dx.doi.org/10.1002/jcb.25857
  • Gao C, Fujinawa R, Yoshida T, Ueno M, Ota F, Kizuka Y, Hirayama T, Korekane H, Kitazume S, Maeno T, Ohtsubo K, Yoshida K, Yamaguchi Y, Lepenies B, Aretz J, Rademacher C, Kabata H, Hegab AE, Seeberger PH, Betsuyaku T, Kida K, Taniguchi N. A keratan sulfate disaccharide prevents inflammation and the progression of emphysema in murine models. Am J Physiol Lung Cell Mol Physiol. 2016 Dec 23:ajplung.00151.2016. doi:, 10.1152/ajplung.00151.2016. PubMed 28011617 DOI http://dx.doi.org/10.1152/ajplung.00151.2016
  • Inoue A, Matsumoto I, Tanaka Y, Umeda N, Takai C, Kawaguchi H, Ebe H, Yoshida H, Matsumoto Y, Segawa S, Takahashi S, Sumida T. TIARP attenuates autoantibody-mediated arthritis via the suppression of neutrophil migration by reducing CXCL2/CXCR2 and IL-6 expression. Sci Rep. 2016 Dec 20;6:38684. doi: 10.1038/srep38684. PubMed 27995997 DOI http://dx.doi.org/10.1038/srep38684
  • Skiba DS, Nosalski R, Mikolajczyk TP, Siedlinski M, Rios FJ, Montezano AC, Jawien J, Olszanecki R, Korbut R, Czesnikiewicz-Guzik M, Touyz RM, Guzik TJ. Antiatherosclerotic effect of Ang- (1-7) non-peptide mimetic (AVE 0991) is mediated by inhibition of perivascular and plaque inflammation in early atherosclerosis. Br J Pharmacol. 2016 Dec 9. doi: 10.1111/bph.13685. PubMed 27935022 DOI http://dx.doi.org/10.1111/bph.13685
  • Chan KC, Yu MH, Lin MC, Huang CN, Chung DJ, Lee YJ, Wu CH, Wang CJ. Pleiotropic effects of acarbose on atherosclerosis development in rabbits are mediated via upregulating AMPK signals. Sci Rep. 2016 Dec 7;6:38642. doi: 10.1038/srep38642. PubMed 27924924 DOI http://dx.doi.org/10.1038/srep38642
  • Tsai CS, Lin YW, Huang CY, Shih CM, Tsai YT, Tsao NW, Lin CS, Shih CC, Jeng H, Lin FY. Thrombomodulin regulates monocye differentiation via PKCdelta and ERK1/2 pathway in vitro and in atherosclerotic artery. Sci Rep. 2016 Dec 2;6:38421. doi: 10.1038/srep38421. PubMed 27910925 DOI http://dx.doi.org/10.1038/srep38421
  • Umeda K, Iritani S, Fujishiro H, Sekiguchi H, Torii Y, Habuchi C, Kuroda K, Kaibuchi K, Ozaki N. Immunohistochemical evaluation of the GABAergic neuronal system in the prefrontal cortex of a DISC1 knockout mouse model of schizophrenia. Synapse. 2016 Dec;70(12):508-518. doi: 10.1002/syn.21924. Epub 2016 Aug 1. PubMed 27421906 DOI http://dx.doi.org/10.1002/syn.21924
  • Sole-Domenech S, Cruz DL, Capetillo-Zarate E, Maxfield FR. The endocytic pathway in microglia during health, aging and Alzheimer's disease. Ageing Res Rev. 2016 Dec;32:89-103. doi: 10.1016/j.arr.2016.07.002. Epub 2016 Jul, 12. PubMed 27421577 DOI http://dx.doi.org/10.1016/j.arr.2016.07.002
  • Coutant F, Miossec P. Altered dendritic cell functions in autoimmune diseases: distinct and overlapping profiles. Nat Rev Rheumatol. 2016 Dec;12(12):703-715. doi: 10.1038/nrrheum.2016.147. Epub, 2016 Sep 22. PubMed 27652503 DOI http://dx.doi.org/10.1038/nrrheum.2016.147
  • Zhang Q, Zhang C, Chang F, Liang K, Yin X, Li X, Zhao K, Niu Q, Tian Z. Wip 1 inhibits intestinal inflammation in inflammatory bowel disease. Cell Immunol. 2016 Dec;310:63-70. doi: 10.1016/j.cellimm.2016.07.012. Epub 2016, Jul 25. PubMed 27687530 DOI http://dx.doi.org/10.1016/j.cellimm.2016.07.012
  • Yoo SA, Leng L, Kim BJ, Du X, Tilstam PV, Kim KH, Kong JS, Yoon HJ, Liu A, Wang T, Song Y, Sauler M, Bernhagen J, Ritchlin CT, Lee P, Cho CS, Kim WU, Bucala R. MIF allele-dependent regulation of the MIF coreceptor CD44 and role in rheumatoid arthritis. Proc Natl Acad Sci U S A. 2016 Nov 21. pii: 201612717. PubMed 27872288 DOI http://dx.doi.org/10.1073/pnas.1612717113
  • Gennarini G, Bizzoca A, Picocci S, Puzzo D, Corsi P, Furley AJ. The role of Gpi-anchored axonal glycoproteins in neural development and neurological disorders. Mol Cell Neurosci. 2016 Nov 18. pii: S1044-7431(16)30240-8. doi:, 10.1016/j.mcn.2016.11.006. PubMed 27871938 DOI http://dx.doi.org/10.1016/j.mcn.2016.11.006
  • Venkatesh K, Sen D. Mesenchymal stem cells as a source of dopaminergic neurons: A potential cell based therapy for Parkinson's disease. Curr Stem Cell Res Ther. 2016 Nov 14. PubMed 27842480
  • Shang S, Yang YM, Zhang H, Tian L, Jiang JS, Dong YB, Zhang K, Li B, Zhao WD, Fang WG, Chen YH. Intracerebral GM-CSF contributes to transendothelial monocyte migration in APP/PS1 Alzheimer's disease mice. J Cereb Blood Flow Metab. 2016 Nov;36(11):1978-1991. Epub 2016 Jul 21. PubMed 27444968 DOI http://dx.doi.org/10.1177/0271678X16660983
  • Adapala NS, Yamaguchi R, Phipps M, Aruwajoye O, Kim HK. Necrotic Bone Stimulates Proinflammatory Responses in Macrophages through the Activation of Toll-Like Receptor 4. Am J Pathol. 2016 Nov;186(11):2987-2999. doi: 10.1016/j.ajpath.2016.06.024. Epub , 2016 Sep 17. PubMed 27648614 DOI http://dx.doi.org/10.1016/j.ajpath.2016.06.024