Cardiovascular Disorders

  • Xiao J, Jin K, Wang J, Ma J, Zhang J, Jiang N, Wang H, Luo X, Fei J, Wang Z, Yang X, Ma D. Conditional knockout of TFPI-1 in VSMCs of mice accelerates atherosclerosis by enhancing AMOT/YAP pathway. Int J Cardiol. 2017 Feb 1;228:605-614. doi: 10.1016/j.ijcard.2016.11.195. Epub, 2016 Nov 12. PubMed 27875740 DOI http://dx.doi.org/10.1016/j.ijcard.2016.11.195
  • Luo Y, Duan H, Qian Y, Feng L, Wu Z, Wang F, Feng J, Yang D, Qin Z, Yan X. Macrophagic CD146 promotes foam cell formation and retention during atherosclerosis. Cell Res. 2017 Jan 13. doi: 10.1038/cr.2017.8. PubMed 28084332 DOI http://dx.doi.org/10.1038/cr.2017.8
  • Rossignoli A, Shang MM, Gladh H, Moessinger C, Foroughi Asl H, Talukdar HA, Franzen O, Mueller S, Bjorkegren JL, Folestad E, Skogsberg J. Poliovirus Receptor-Related 2: A Cholesterol-Responsive Gene Affecting Atherosclerosis Development by Modulating Leukocyte Migration. Arterioscler Thromb Vasc Biol. 2017 Jan 5. pii: ATVBAHA.116.308715. doi:, 10.1161/ATVBAHA.116.308715. PubMed 28062492 DOI http://dx.doi.org/10.1161/ATVBAHA.116.308715
  • Mumby S, Gambaryan N, Meng C, Perros F, Humbert M, Wort SJ, Adcock IM. Bromodomain and extra-terminal protein mimic JQ1 decreases inflammation in human vascular endothelial cells: Implications for pulmonary arterial hypertension. Respirology. 2017 Jan;22(1):157-164. doi: 10.1111/resp.12872. Epub 2016 Aug 18. PubMed 27539364 DOI http://dx.doi.org/10.1111/resp.12872
  • Fujisawa T, Wang K, Niu XL, Egginton S, Ahmad S, Hewett P, Kontos CD, Ahmed A. Angiopoietin-1 promotes atherosclerosis by increasing the proportion of circulating Gr1+ monocytes. Cardiovasc Res. 2017 Jan;113(1):81-89. doi: 10.1093/cvr/cvw223. PubMed 28069704 DOI http://dx.doi.org/10.1093/cvr/cvw223
  • Celic T, Meuth VM, Six I, Massy ZA, Metzinger L. The mir-221/222 Cluster is a Key Player in Vascular Biology via the Fine-Tuning of Endothelial Cell Physiology. Curr Vasc Pharmacol. 2017;15(1):40-46. PubMed 27633456
  • Ghousifam N, Mortazavian H, Bhowmick R, Vasquez Y, Blum FD, Gappa-Fahlenkamp H. A three-dimensional in vitro model to demonstrate the haptotactic effect of monocyte chemoattractant protein-1 on atherosclerosis-associated monocyte migration. Int J Biol Macromol. 2016 Dec 29;97:141-147. doi: 10.1016/j.ijbiomac.2016.12.072. PubMed 28041913 DOI http://dx.doi.org/10.1016/j.ijbiomac.2016.12.072
  • Okada M, Murata N, Yamawaki H. Canstatin stimulates migration of rat cardiac fibroblasts via secretion of matrix metalloproteinase-2. Am J Physiol Cell Physiol. 2016 Dec 21:ajpcell.00329.2015. doi:, 10.1152/ajpcell.00329.2015. PubMed 28003226 DOI http://dx.doi.org/10.1152/ajpcell.00329.2015
  • Skiba DS, Nosalski R, Mikolajczyk TP, Siedlinski M, Rios FJ, Montezano AC, Jawien J, Olszanecki R, Korbut R, Czesnikiewicz-Guzik M, Touyz RM, Guzik TJ. Antiatherosclerotic effect of Ang- (1-7) non-peptide mimetic (AVE 0991) is mediated by inhibition of perivascular and plaque inflammation in early atherosclerosis. Br J Pharmacol. 2016 Dec 9. doi: 10.1111/bph.13685. PubMed 27935022 DOI http://dx.doi.org/10.1111/bph.13685
  • Chan KC, Yu MH, Lin MC, Huang CN, Chung DJ, Lee YJ, Wu CH, Wang CJ. Pleiotropic effects of acarbose on atherosclerosis development in rabbits are mediated via upregulating AMPK signals. Sci Rep. 2016 Dec 7;6:38642. doi: 10.1038/srep38642. PubMed 27924924 DOI http://dx.doi.org/10.1038/srep38642
  • Tsai CS, Lin YW, Huang CY, Shih CM, Tsai YT, Tsao NW, Lin CS, Shih CC, Jeng H, Lin FY. Thrombomodulin regulates monocye differentiation via PKCdelta and ERK1/2 pathway in vitro and in atherosclerotic artery. Sci Rep. 2016 Dec 2;6:38421. doi: 10.1038/srep38421. PubMed 27910925 DOI http://dx.doi.org/10.1038/srep38421
  • Beneit N, Fernandez-Garcia CE, Martin-Ventura JL, Perdomo L, Escribano O, Michel JB, Garcia-Gomez G, Fernandez S, Diaz-Castroverde S, Egido J, Gomez-Hernandez A, Benito M. Expression of insulin receptor (IR) A and B isoforms, IGF-IR, and IR/IGF-IR hybrid receptors in vascular smooth muscle cells and their role in cell migration in atherosclerosis. Cardiovasc Diabetol. 2016 Dec 1;15(1):161. PubMed 27905925 DOI http://dx.doi.org/10.1186/s12933-016-0477-3
  • Garcia-Redondo AB, Aguado A, Briones AM, Salaices M. NADPH oxidases and vascular remodeling in cardiovascular diseases. Pharmacol Res. 2016 Dec;114:110-120. doi: 10.1016/j.phrs.2016.10.015. Epub 2016, Oct 20. PubMed 27773825 DOI http://dx.doi.org/10.1016/j.phrs.2016.10.015
  • Worbs T, Hammerschmidt SI, Forster R. Dendritic cell migration in health and disease. Nat Rev Immunol. 2016 Nov 28. doi: 10.1038/nri.2016.116. PubMed 27890914 DOI http://dx.doi.org/10.1038/nri.2016.116
  • Jenkinson SE, Brown LJ, Ombor J, Milburn JA, Smulders-Srinivasan T, Veuger S, Edwards DR, Bass R. Identification of novel peptide motifs in the serpin maspin that affect vascular smooth muscle cell function. Biochim Biophys Acta. 2016 Nov 22. pii: S0167-4889(16)30306-8. doi:, 10.1016/j.bbamcr.2016.11.019. PubMed 27888098 DOI http://dx.doi.org/10.1016/j.bbamcr.2016.11.019
  • Li L, Pan H, Wang H, Li X, Bu X, Wang Q, Gao Y, Wen G, Zhou Y, Cong Z, Yang Y, Tang C, Liu Z. Interplay between VEGF and Nrf2 regulates angiogenesis due to intracranial venous hypertension. Sci Rep. 2016 Nov 21;6:37338. doi: 10.1038/srep37338. PubMed 27869147 DOI http://dx.doi.org/10.1038/srep37338
  • de Jong RJ, Leoni G, Drechsler M, Soehnlein O. The advantageous role of annexin A1 in cardiovascular disease. Cell Adh Migr. 2016 Nov 18:0. PubMed 27860536 DOI http://dx.doi.org/10.1080/19336918.2016.1259059
  • Xingjuan C, Qian S, Hoggatt A, Tang H, Hacker TA, Obukhov AG, Herring PB, Seye CI. Endothelial Cell-Specific Deletion of P2Y2 Receptor Promotes Plaque Stability in Atherosclerosis-Susceptible ApoE-Null Mice. Arterioscler Thromb Vasc Biol. 2016 Nov 17. pii: ATVBAHA.116.308561. PubMed 27856454 DOI http://dx.doi.org/10.1161/ATVBAHA.116.308561
  • Baumer Y, McCurdy S, Alcala M, Mehta N, Lee BH, Ginsberg MH, Boisvert WA. CD98 regulates vascular smooth muscle cell proliferation in atherosclerosis. Atherosclerosis. 2016 Nov 16. pii: S0021-9150(16)31485-X. doi:, 10.1016/j.atherosclerosis.2016.11.017. PubMed 28012647 DOI http://dx.doi.org/10.1016/j.atherosclerosis.2016.11.017
  • Ramachandran S, Vinitha A, Kartha CC. Cyclophilin A enhances macrophage differentiation and lipid uptake in high glucose conditions: a cellular mechanism for accelerated macro vascular disease in diabetes mellitus. Cardiovasc Diabetol. 2016 Nov 3;15(1):152. PubMed 27809851 DOI http://dx.doi.org/10.1186/s12933-016-0467-5
  • Bochenek ML, Schutz E, Schafer K. Endothelial cell senescence and thrombosis: Ageing clots. Thromb Res. 2016 Nov;147:36-45. doi: 10.1016/j.thromres.2016.09.019. Epub 2016, Sep 20. PubMed 27669126 DOI http://dx.doi.org/10.1016/j.thromres.2016.09.019
  • Pereira A, Palma Dos Reis R, Rodrigues R, Sousa AC, Gomes S, Borges S, Ornelas I, Freitas AI, Guerra G, Henriques E, Rodrigues M, Freitas S, Freitas C, Brehm A, Pereira D, Mendonca MI. Association of ADAMTS7 gene polymorphism with cardiovascular survival in coronary artery disease. Physiol Genomics. 2016 Nov 1;48(11):810-815. doi:, 10.1152/physiolgenomics.00059.2016. Epub 2016 Sep 9. PubMed 27614204 DOI http://dx.doi.org/10.1152/physiolgenomics.00059.2016
  • Saita E, Miura K, Suzuki-Sugihara N, Miyata K, Ikemura N, Ohmori R, Ikegami Y, Kishimoto Y, Kondo K, Momiyama Y. Plasma Soluble Endoglin Levels Are Inversely Associated With the Severity of Coronary Atherosclerosis. Arterioscler Thromb Vasc Biol. 2016 Oct 27. pii: ATVBAHA.116.308494. PubMed 27789477 DOI http://dx.doi.org/10.1161/ATVBAHA.116.308494
  • Liu R, Jin JP. Deletion of calponin 2 in macrophages alters cytoskeleton-based functions and attenuates the development of atherosclerosis. J Mol Cell Cardiol. 2016 Oct;99:87-99. doi: 10.1016/j.yjmcc.2016.08.019. Epub, 2016 Aug 26. PubMed 27575021 DOI http://dx.doi.org/10.1016/j.yjmcc.2016.08.019
  • Altabas V, Altabas K, Kirigin L. Endothelial progenitor cells (EPCs) in ageing and age-related diseases: How currently available treatment modalities affect EPC biology, atherosclerosis, and cardiovascular outcomes. Mech Ageing Dev. 2016 Oct;159:49-62. doi: 10.1016/j.mad.2016.02.009. Epub 2016, Feb 23. PubMed 26919825 DOI http://dx.doi.org/10.1016/j.mad.2016.02.009
  • Herbin O, Regelmann AG, Ramkhelawon B, Weinstein EG, Moore KJ, Alexandropoulos K. Monocyte Adhesion and Plaque Recruitment During Atherosclerosis Development Is Regulated by the Adapter Protein Chat-H/SHEP1. Arterioscler Thromb Vasc Biol. 2016 Sep;36(9):1791-801. doi:, 10.1161/ATVBAHA.116.308014. Epub 2016 Jul 14. PubMed 27417580 DOI http://dx.doi.org/10.1161/ATVBAHA.116.308014
  • Tang L, Pei H, Yang Y, Wang X, Wang T, Gao E, Li D, Yang Y, Yang D. The inhibition of calpains ameliorates vascular restenosis through MMP2/TGF-beta1 pathway. Sci Rep. 2016 Jul 25;6:29975. doi: 10.1038/srep29975. PubMed 27453531 DOI http://dx.doi.org/10.1038/srep29975
  • Mahmoud MM, Kim HR, Xing R, Hsiao S, Mammoto A, Chen J, Serbanovic-Canic J, Feng S, Bowden NP, Maguire R, Ariaans M, Francis SE, Weinberg PD, van der Heiden K, Jones EA, Chico TJ, Ridger V, Evans PC. TWIST1 Integrates Endothelial Responses to Flow in Vascular Dysfunction and Atherosclerosis. Circ Res. 2016 Jul 22;119(3):450-62. doi: 10.1161/CIRCRESAHA.116.308870. Epub, 2016 May 31. PubMed 27245171 DOI http://dx.doi.org/10.1161/CIRCRESAHA.116.308870
  • Chiapparo G, Lin X, Lescroart F, Chabab S, Paulissen C, Pitisci L, Bondue A, Blanpain C. Mesp1 controls the speed, polarity, and directionality of cardiovascular progenitor migration. J Cell Biol. 2016 May 23;213(4):463-77. doi: 10.1083/jcb.201505082. Epub 2016 May, 16. PubMed 27185833 DOI http://dx.doi.org/10.1083/jcb.201505082
  • Kim J, Seo M, Kim SK, Bae YS. Flagellin-induced NADPH oxidase 4 activation is involved in atherosclerosis. Sci Rep. 2016 May 5;6:25437. doi: 10.1038/srep25437. PubMed 27146088 DOI http://dx.doi.org/10.1038/srep25437