Pages

Event search results

  • Date:15MondayOctober 2018

    Special Guest Seminar by Prof. Robert A. Weinberg

    More information
    Time
    09:30 - 10:30
    Title
    Epigenetic Mechanisms of Tumor Progression
    Location
    Nella and Leon Benoziyo Building for Biological Sciences
    Auditorium
    Lecturer
    Robert A. Weinberg Ph.D
    Whitehead Institute/MIT Biology Department Cambridge Massachusetts
    Organizer
    Department of Molecular Cell Biology
    Contact
    Lecture
  • Date:15MondayOctober 2018

    Life Science Colloquium

    More information
    Time
    11:00 - 12:00
    Title
    Senescent cells in health and disease
    Location
    Dolfi and Lola Ebner Auditorium
    Lecturer
    Prof. Jan van Deursen
    Mayo Clinic, Minnesota
    Organizer
    Life Sciences
    Contact
    Colloquia
  • Date:15MondayOctober 2018

    "Jupiter’s deep atmosphere revealed by Juno"

    More information
    Time
    11:00 - 12:15
    Location
    Gerhard M.J. Schmidt Lecture Hall
    Lecturer
    Prof. Yohai Kaspi
    Earth and Planetary Sciences, WIS
    Organizer
    Faculty of Chemistry
    Contact
    Colloquia
  • Date:15MondayOctober 2018

    The transmembrane proteins LRIG1 and LRIG2 differentially affect skin carcinogenesis

    More information
    Time
    14:00 - 15:00
    Title
    Special Guest
    Location
    Max and Lillian Candiotty Building
    Auditorium
    Lecturer
    Dr. Maik Dahlhoff
    Institute of Molecular Animal Breeding and Biotechnology, LMU Muenchen, Germany
    Organizer
    Department of Biological Regulation
    Contact
    Lecture
  • Date:15MondayOctober 2018

    Building your Personal Brand: LinkedIn insights

    More information
    Time
    15:00 - 16:00
    Location
    Dolfi and Lola Ebner Auditorium
    Lecturer
    Tamir Huberman
    IDC Herzlia
    Organizer
    Feinberg Graduate School
    Contact
    Lecture
  • Date:16TuesdayOctober 2018

    Expeditious Synthesis of Bacterial Glycoconjugates

    More information
    Time
    11:00 - 12:00
    Location
    Helen and Milton A. Kimmelman Building
    Dov Elad Room
    Lecturer
    Prof. Suvarn S. Kulkarni
    Indian Institute of Technology Bombay
    Organizer
    Department of Organic Chemistry
    Contact
    AbstractShow full text abstract about Expeditious Synthesis of Bacterial Glycoconjugates Suvarn ...»
    Expeditious Synthesis of Bacterial Glycoconjugates
    Suvarn S. Kulkarni
    Department of Chemistry, IIT Bombay, Powai, Mumbai-400076
    Bacterial glycoconjugates are comprised of rare D and L deoxy amino sugars, which are not present on the human cell surface. This peculiar structural difference allows discrimination between the pathogen and the host cell and offers avenues for target-specific drug discovery and carbohydrate-based vaccine development. However, they cannot be isolated with sufficient purity in acceptable amounts, and therefore chemical synthesis is a crucial step toward the development of these products.1 We recently established short and convenient methodologies for the synthesis of orthogonally protected bacterial D and L-deoxy amino hexopyranoside and glycosamine building blocks starting from cheaply available D-mannose and L-rhamnose.2-4 The one-pot protocols rely on highly regioselective nucleophilic displacements of triflates. These procedures have been applied to the synthesis of various bacterial glycoconjugates2-8 (Figure 1) as well as metabolic oligosaccharide engineering.7


    1) Emmadi, M.; Kulkarni, S. S. Nat. Prod. Rep. 2014, 31, 870-879. 2) Emmadi, M.; Kulkarni, S. S. Nature Protocols 2013, 8, 1870-1889. 3) Sanapala, S. R.; Kulkarni S. S. J. Am. Chem. Soc. 2016, 138, 4938−4947. 4) Sanapala, S. R.; Kulkarni S. S. Org. Lett. 2016, 18, 3790–3793. 5) Podilapu, A. R.; Kulkarni, S. S. Org. Lett. 2014, 16, 4336-4339. 6) Sanapala, S. R.; Kulkarni, S. S., Chem. Eur. J. 2014, 20, 3578-3583. 7) Clark, E.; I.; Emmadi, M.; Krupp, K. L.; Podilapu, A. R.; Helble, J. D.; Kulkarni, S. S.; Dube, D. H. ACS Chem Biol 2016, 11, 3365-3373. 8) Podilapu, A. R.; Kulkarni, S. S. Org. Lett. 2017, 19, 5466-5469.
    Lecture
  • Date:16TuesdayOctober 2018

    “Beauty and Benefits of cryo-EM; Resolving the 3D structure of the Type VII secretion system in Mycobacterium tuberculosis”

    More information
    Time
    14:00 - 15:00
    Location
    Helen and Milton A. Kimmelman Building
    Dov Elad Room
    Lecturer
    Prof. Peter Peters
    Maastricht Multimodal Molecular Imaging institute (M4I).
    Organizer
    Department of Structural Biology
    Contact
    Lecture
  • Date:17WednesdayOctober 2018

    G-INCPM-Special Seminar - Prof. Rony Seger, Department of Biological Regulation, Weizmann Institute - "Targeting the nuclear translocation of MAPKs as a novel anti-inflammatory and anti cancer therapy"

    More information
    Time
    11:00 - 12:15
    Location
    Nancy and Stephen Grand Israel National Center for Personalized Medicine
    Auditorium
    Organizer
    Department of Biomolecular Sciences
    Contact
    AbstractShow full text abstract about A hallmark of MAPK signaling is their nuclear translocation ...»
    A hallmark of MAPK signaling is their nuclear translocation upon stimulation, which is necessary for their physiological/pathological functions. We have identified two novel, distinct, regulated nuclear translocation mechanisms for ERK1/2 and JNK/p38, of which we made use of as a promising therapeutic approach. We developed a myristoylated, NTS-derived phosphomimetic peptide (EPE peptide), which blocked ERK1/2 nuclear translocation. In culture, the EPE peptide induced apoptosis of melanoma cells, inhibited the proliferation of other cancer cells but had no effect on immortalized cells. Combination of the EPE peptide and the MEK inhibitor had synergistic antitumor activity in mutated NRAS, BRAF and NF1 melanoma and Kras pancreatic cells. In xenograft models, the peptide was significantly more effective than BRAF inhibitors in preventing tumor recurrence of treatment-eradicated melanoma xenografts. We also developed p38-derived myristoylated peptide, termed PERY peptide, which inhibited the importin interaction with JNK1/2 and p38α/β and prevented their nuclear translocation. This peptide affected viability of several breast cancer-derived cell lines, and significantly reduced inflammation and intestinal damage in a mouse model of colitis. Moreover, the peptide inhibited inflammation-induced colorectal cancer in a AOM/DSS mouse model. Taken together, both the cancer and inflammatory models support the use of nuclear translocation of MAPKs as a novel drug target for signaling-related diseases.
    Lecture
  • Date:17WednesdayOctober 2018

    Algebraic Geometry and Representation Theory Seminar

    More information
    Time
    11:15 - 12:30
    Title
    Cyclic Elements in Semisimple Lie Algebras
    Location
    Jacob Ziskind Building
    Room 155
    Lecturer
    Professor Elashvili
    Razmadze Mathematical Institute
    Organizer
    Faculty of Mathematics and Computer Science
    Algebraic Geometry and Representation Theory Seminar, Department of Computer Science and Applied Mathematics
    Algebraic Geometry and Representation Theory Seminar, Department of Mathematics
    Algebraic Geometry and Representation Theory Seminar
    Contact
    Lecture
  • Date:17WednesdayOctober 2018

    Machine Learning and Statistics Seminar

    More information
    Time
    11:15 - 12:30
    Title
    Harmonizing Fully Optimal Designs with Classic Randomization in Fixed Trial Experiments
    Organizer
    Faculty of Mathematics and Computer Science
    Faculty of Mathematical Sciences Seminar
    Contact
    Lecture
  • Date:17WednesdayOctober 2018

    Machine Learning and Statistics Seminar

    More information
    Time
    11:15 - 12:30
    Title
    Harmonizing Fully Optimal Designs with Classic Randomization in Fixed Trial Experiments
    Lecturer
    Adam Kapelner
    Queen's College, NYC
    Organizer
    Faculty of Mathematics and Computer Science
    Faculty of Mathematical Sciences Seminar
    Contact
    Lecture
  • Date:17WednesdayOctober 2018

    Algebraic Geometry and Representation Theory Seminar

    More information
    Time
    11:15 - 12:30
    Title
    Cyclic elements in semisimple Lie algebras
    Location
    Jacob Ziskind Building
    Room 155
    Lecturer
    Alexander Elashvili
    Razmadze Mathematical Institute
    Organizer
    Faculty of Mathematics and Computer Science
    Mathematical Analysis and Applications Seminar
    Contact
    Lecture
  • Date:17WednesdayOctober 2018

    Algebraic Geometry and Representation Theory Seminar

    More information
    Time
    11:15 - 12:30
    Title
    Cyclic elements in semisimple Lie algebras
    Location
    Jacob Ziskind Building
    Room 155
    Lecturer
    Alexander Elashvili
    Razmadze Mathematical Institute
    Organizer
    Faculty of Mathematics and Computer Science
    Mathematical Analysis and Applications Seminar
    Contact
    Lecture
  • Date:17WednesdayOctober 2018

    Algebraic Geometry and Representation Theory Seminar

    More information
    Time
    11:15 - 12:30
    Title
    Cyclic elements in semisimple Lie algebras
    Location
    Jacob Ziskind Building
    Room 155
    Lecturer
    Alexander Elashvili
    Razmadze Mathematical Institute
    Organizer
    Faculty of Mathematics and Computer Science
    Mathematical Analysis and Applications Seminar
    Contact
    Lecture
  • Date:18ThursdayOctober 2018

    Information processing at hippocampal synapses

    More information
    Time
    12:30
    Location
    Gerhard M.J. Schmidt Lecture Hall
    Lecturer
    Prof. J. Simon Wiegert
    Center for Molecular Neurobiology Hamburg (ZMNH) University Medical Center Hamburg-Eppendorf
    Organizer
    Department of Neurobiology
    Contact
    DetailsShow full text description of Host: Dr. Ofer Yizhar ofer.yizhar@weizmann.ac.il tel: 6957...»
    Host: Dr. Ofer Yizhar ofer.yizhar@weizmann.ac.il tel: 6957
    For assistance with accessibility issues, please contact naomi.moses@weizmann.ac.il
    AbstractShow full text abstract about Synapses change their strength in response to specific activ...»
    Synapses change their strength in response to specific activity patterns. This functional plasticity is assumed to be the brain’s primary mechanism for information storage. We combine optogenetic and chemogenetic control of synapses in rat hippocampal slice cultures with calcium and glutamate imaging of their spines and boutons. This approach enables us to perform all-optical quantal analysis of synaptic transmission, to induce long-term potentiation (LTP), long-term depression (LTD), or both forms of plasticity in sequence, to chronically manipulate activity and to follow the fate of individual synapses for 7 days. We ask how plasticity and activity are integrated at Schaffer collateral synapses over time. Our findings suggest that activity-dependent changes in the transmission strength of individual synapses are transient, but have long-lasting consequences for synaptic lifetime.
    Lecture
  • Date:21SundayOctober 2018

    Memorial Day for Yitzhak Rabin

    More information
    Time
    11:00 - 12:30
    Contact
    Lecture
  • Date:21SundayOctober 2018

    Major elements in seawater – a tool for quantifying large-scale processes in the ocean

    More information
    Time
    11:00
    Location
    Sussman Family Building for Environmental Sciences
    M. Magaritz Seminar Room
    Lecturer
    Zvika Steiner
    University of Cambridge
    Organizer
    Department of Earth and Planetary Sciences
    Contact
    Lecture
  • Date:22MondayOctober 2018

    "Composition-Dependent Functions of Biomolecular Condensates"

    More information
    Time
    11:00 - 12:15
    Location
    Gerhard M.J. Schmidt Lecture Hall
    Lecturer
    Prof. Michael Rosen
    UT Southwestern Medical Center
    Organizer
    Faculty of Chemistry
    Contact
    Colloquia
  • Date:22MondayOctober 2018

    G-INCPM - Special Seminar - Dr. Wolfgang Mann, CEO, BlueCatBio GmbH, Germany - "Blue Washer: the most cost-effective tool to improve data quality (z') for adherent cellular assays"

    More information
    Time
    11:00 - 12:15
    Location
    Nancy and Stephen Grand Israel National Center for Personalized Medicine
    Auditorium
    Organizer
    Department of Biomolecular Sciences
    Contact
    AbstractShow full text abstract about Since its introduction in 2015 the BlueWasher has rapidly be...»
    Since its introduction in 2015 the BlueWasher has rapidly become the de-facto standard for media change & cell wash in adherent cellular assays.
    The BlueWasher uses centrifugation instead of aspiration to remove liquids from all plate formats, including 1536w, eliminating background and variability at their (assay) sources. Highly reproducible residual volumes 10x lower than conventional plate washers enable imagers to produce cleaner images, raising z' 0.1-0.3 for typical adherent cellular assays. Higher z' means to miss fewer active compounds and reduce false positives to re-screen. BlueWasher immediately improves screening economics without complex assay or automation changes, delivering unparalleled ROI and direct boost to overall drug discovery productivity.
    A technical introduction into centrifugation based cell wash / media changed will be followed by a number of examples discussing improvement of data quality in HTS / HCS. Other bead based applications like nucleic acids extraction or protein binding assays will be presented as well.

    Lecture
  • Date:22MondayOctober 2018

    Genomic and Epigenomics club

    More information
    Time
    11:00 - 12:00
    Location
    Camelia Botnar Building
    Botnar Auditorium
    Lecturer
    Prof. Eske Willerslev
    Organizer
    Life Sciences
    Contact
    Lecture

Pages