Cell Migration Gateway Logo

Consortium Updates

Welcome to the Cell Migration Consortium's updates page, where we highlight major additions of data and information, and outline some of the publications appearing as a result of the Consortium's activities.

Archive

  1. 2002
  2. 2003
  3. 2004
  4. 2005
  5. 2006
  6. 2007
  7. 2008
  8. 2009
  9. 2010

  • December 2002

    1. Adhesion and cytoskeletal molecules get the Green light

    • Adhesion and cytoskeletal molecules get the Green light

      In a publication in the November edition of Current Biology, the Horwitz laboratory describes a GFP based expression cloning strategy to identify novel adhesion and cytoskeletal molecules and in so doing described the identification of a novel microtubule-associated protein that regulates microtubule organization and cytokinesis.

      • Manabe R, Whitmore L, Weiss JM, Horwitz AR. Identification of a novel microtubule-associated protein that regulates microtubule organization and cytokinesis by using a GFP-screening strategy. Curr Biol. 2002 Nov 19;12(22):1946-51. PubMed

    return to top

  • October 2002

    1. Reviews on the structural basis of integrin activation and their role as bidirectional, allosteric signaling machines.
    2. New Migration Models for protrusion and adhesive signaling.

    • Reviews on the structural basis of integrin activation and their role as bidirectional, allosteric signaling machines.

      • Liddington RC, Ginsberg MH.Integrin activation takes shape. J Cell Biol. 2002;158(5):833-9. PubMed

      • Hynes RO. Integrins: bidirectional, allosteric signaling machines. Cell. 2002;110(6):673-87. PubMed

    • New Migration Models for protrusion and adhesive signaling.

      1) Application of Bayesian networks to model focal adhesion kinase (FAK) and extracellular signal-regulated kinase (ERK) in response to fibronectin binding to an integrin. 2) Mathematical model describing actin dynamics in protrusion.

      • Sachs K , Gifford D , Jaakkola T , Sorger P , Lauffenburger DA. Bayesian network approach to cell signaling pathway modeling. Sci STKE. 2002;2002(148):PE38. PubMed

      • Mogilner A , Edelstein-Keshet L. Regulation of actin dynamics in rapidly moving cells: a quantitative analysis. Biophys J. 2002;83(3):1237-58. PubMed

    return to top

  • July 2002

    1. A featured article highlights computational Cell Biology

    • A featured article highlights computational Cell Biology

      Recent Nature Jobs article highlights computational cell biology as an emerging discipline, combining biology with maths and computer science with the ultimate goal of generating computer models of the living cells.

    return to top

  • February 2002

    1. Transgenic mice studies demonstrating a role for integrins in blood vessel development

    • Transgenic mice studies demonstrating a role for integrins in blood vessel development

      In the January edition of Nature Medicine Consortium scientists report on studies using transgenic mice lacking beta3 integrin or beta3 and beta5 integrins, demonstrating a role for these integrins in blood vessel development.

      • Reynolds LE, Wyder L, Lively JC, Taverna D, Robinson SD, Huang X, Sheppard D, Hynes RO, Hodivala-Dilke KM. Enhanced pathological angiogenesis in mice lacking beta3 integrin or beta3 and beta5 integrins. Nature Medicine 2002;8(1):27-34. PubMed

    return to top

2002